ELISA COPS4 anti-

Quantity :50µL Clone Number: Aliases:CH4 antibody; COP9 (constitutive photomorphogenic) homolog subunit 4 antibody; COP9 complex homolog subunit 4 antibody; COP9 complex S4 antibody; COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) antibody; COP9 constitutive photomorphogenic homolog subunit 4 antibody; COP9 signalosome complex subunit 4 antibody; COP9 signalosome subunit 4 antibody; COPS4 antibody; CSN complex subunit 4 antibody; CSN4 antibody; CSN4 SCHPO antibody; CSN4_ antibody; DCH4 antibody; JAB1 containing signalosome subunit 4 antibody; JAB1-containing signalosome subunit 4 antibody; MGC94896 antibody; SGN4 antibody; Signalosome subunit 4 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9BT78 Immunogen:Recombinant COP9 signalosome complex subunit 4 protein (1-310AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200 Background:Component of the COP9 signalosome complex (CSN), a complex involved in various cellµLar and developmental processes. The CSN complex is an essential regµLator of the ubiquitin (Ubl) conjµgation pathway by mediating the deneddylation of the cµLlin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cµLlin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:COPS4 Research Areas:Others