ELISA RNF34 anti-

Quantity :50µL Clone Number: Aliases:CARP 1 antibody; CARP-1 antibody; CARP1 antibody; Caspase regµLator CARP1 antibody; Caspases-8 and -10-associated RING finger protein 1 antibody; E3 ubiquitin-protein ligase RNF34 antibody; FYVE-RING finger protein Momo antibody; hRFI antibody; RING finger homologous to inhibitor of apoptosis protein antibody; RFI antibody; RIF antibody; RIFF antibody; RING finger protein 34 antibody; RING finger protein RIFF antibody; RNF34 antibody; RNF34_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q969K3 Immunogen:Recombinant E3 ubiquitin-protein ligase RNF34 protein (1-220AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:E3 ubiquitin-protein ligase that regµLates several biological processes throµgh the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regµLate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate \\\'Lys-48\\\'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regµLating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regµLates p53/TP53 throµgh its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regµLate p53/TP53 throµgh ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably throµgh ubiquitination thereby indirectly regµLating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, throµgh \\\'Lys-48\\\'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219). Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RNF34 Research Areas:Cell biology