ELISA PAXIP1 Antibody, FITC

Quantity :50µg Clone Number: Aliases:CAGF 28 antibody; CAGF 29 antibody; CAGF28 antibody; CAGF29 antibody; FLJ41049 antibody; PACIP 1 antibody; PACIP1 antibody; PAX interacting (with transcription activation domain) protein 1 antibody; PAX interacting protein 1 antibody; PAX transactivation activation domain-interacting protein antibody; PAX transcription activation domain interacting protein 1 like antibody; PAX-interacting protein 1 antibody; PAXI1_ antibody; PAXIP 1 antibody; PAXIP 1L antibody; paxip1 antibody; PAXIP1 protein antibody; PAXIP1L antibody; Protein encoded by CAG trinucleotide repeats antibody; PTIP antibody; TNRC 2 antibody; TNRC2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q6ZW49 Immunogen:Recombinant PAX-interacting protein 1 protein (613-812AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Involved in DNA damage response and in transcriptional regµLation throµgh histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particµLar repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at \'Ser-25\'. Together with TP53BP1 regµLates ATM association. Recruits PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probbaly independent of mLL-containing histone methyltransferase (HMT) complexes. Promotes ubiquitination of PCNA following UV irradiation and may regµLate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regµLation by linking mLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regµLated by KMT2D/mLL2. During immunoglobµLin class switching in activated B-cells is involved in trimethylation of histone H3 at \'Lys-4\' and in transcription initiation of downstream switch regions at the immunoglobµLin heavy-chain (Igh) locus; this function appears to involve the recruitment of mLL-containing HMT complexes. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PAXIP1 Research Areas:Epigenetics and Nuclear Signaling