ELISA PLEKHG6 anti-

Quantity :50µL Clone Number: Aliases:PLEKHG6 antibody; Pleckstrin homology domain-containing family G member 6 antibody; PH domain-containing family G member 6 antibody; Myosin-interacting guanine nucleotide exchange factor antibody; MyoGEF antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q3KR16 Immunogen:Fusion protein of PLEKHG6 Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC; ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:100-1:300 Background:PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PLEKHG6 Research Areas:Cancer;Cell biology;Signal transduction