ELISA Phospho-SNAI1 (Ser246) anti-

Quantity :100µL Clone Number: Aliases:dJ710H13.1 antibody; Protein sna antibody; Protein snail homolog 1 antibody; Protein snail homolog antibody; SLµgH2 antibody; SNA antibody; Sna protein antibody; SNAH antibody; SNAI antibody; snai1 antibody; SNAI1_ antibody; Snail 1 homolog antibody; Snail 1 zinc finger protein antibody; SNAIL antibody; Snail family transcriptional repressor 1 antibody; Snail homolog 1 (Drosophila) antibody; SNAIL, Drosophila, homolog of, 1 antibody; SNAIL1 antibody; Zinc finger protein SNAI1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O95863 Immunogen:Peptide sequence around phosphorylation site of Serine 246(T-F-S(p)-R-M) derived from SNAI1. Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IF; WB:1:500-1:1000, IF:1:100-1:200 Background: Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regµLation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. Okubo T., Cancer Res. 61:1338-1346(2001). Twigg S.R., Hum. Genet. 105:320-326(1999). Paznekas W.A., Genomics 62:42-49(1999). Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SNAI1 Research Areas:Epigenetics and Nuclear Signaling;Cancer?CardiovascµLar