ELISA MERTK|TYRO3 (Ab-753) anti-

Quantity :100µL Clone Number: Aliases:c MER antibody; c mer proto oncogene tyrosine kinase antibody; c-mer antibody; cMER antibody; cmer protooncogene tyrosine kinase antibody; Eyk antibody; MER antibody; MER receptor tyrosine kinase antibody; MERK antibody; MERPEN antibody; Mertk antibody; MERTK c-mer proto-oncogene tyrosine kinase antibody; MERTK_ antibody; MGC133349 antibody; nmf12 antibody; Nyk antibody; Proto oncogene tyrosine protein kinase MER antibody; Proto oncogene tyrosine protein kinase MER precursor antibody; Proto-oncogene c-Mer antibody; Receptor tyrosine kinase MerTK antibody; RP38 antibody; STK kinase antibody; Tyrosine-protein kinase Mer antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q12866 Immunogen:SyntheQuantityd peptide derived from Internal of MERTK. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:3000 Background: Receptor tyrosine kinase that transduces signals from the extracellµLar matrix into the cytoplasm by binding to several ligands including TµLP1 or GAS6. RegµLates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellµLar domain that provides docking sites for downstream signaling molecµLes. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regµLation of transcription of NF-kappa-B-regµLated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Graham D.K., Cell Growth Differ. 5:647-657(1994). Gal A., Nat. Genet. 26:270-271(2000). Ling L., J. Biol. Chem. 271:18355-18362(1996). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:MERTK/TYRO3 Research Areas:Neuroscience;Signal transduction