ELISA RGS14 anti-

Quantity :100µL Clone Number: Aliases:Highly similar to rap1/rap2 interacting protein antibody; OTTHUMP00000223586 antibody; OTTHUMP00000223587 antibody; RegµLation of G protein signaling 14 antibody; RegµLator of G protein signaling 14 antibody; RegµLator of G protein signalling 14 antibody; RegµLator of G-protein signaling 14 antibody; RGS 14 antibody; RGS14 antibody; RGS14_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O43566 Immunogen:SyntheQuantityd peptide derived from internal of RGS14. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Acts as a regµLator of G protein signaling (RGS). ModµLates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimµLated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modµLator of microtubµLe polymerisation and spindle organization throµgh a G(i)-alpha-dependent mechanism. Plays a role in cell division. Probably required for the nerve growth factor (NGF)-mediated neurite outgrowth. May be involved in visual memory processing capacity and hippocampal-based learning and memory. Lopez-Aranda M.F., Eur. J. Neurosci. 23:2971-2982(2006). Chatterjee T.K., Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases. Puhl H.L. III, Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases. Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RGS14 Research Areas:Signal transduction