ELISA NEUROD1 (Ab-274) anti-

Quantity :100µL Clone Number: Aliases:atonal antibody; basic helix loop helix transcription factor antibody; BETA 2 antibody; Beta cell E box transactivator 2 antibody; BETA2 antibody; BHF 1 antibody; BHF1 antibody; bHLHa3 antibody; class A basic helix loop helix protein 3 antibody; Class A basic helix-loop-helix protein 3 antibody; MODY 6 antibody; MODY6 antibody; NDF1_ antibody; NeuroD antibody; NeuroD1 antibody; Neurogenic differentiation 1 antibody; Neurogenic differentiation factor 1 antibody; neurogenic helix loop helix protein NEUROD antibody; Neuronal differentiation 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13562 Immunogen:SyntheQuantityd non-phosphopeptide derived from Neuro D around the phosphorylation site of serine 272 (P-L-S(p)-P-P-). Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimµLate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regµLation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granµLe cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regµLation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regµLatory elements in genes encoding key transcriptional regµLators of neurogenesis By similarity. Tamimi R., Genomics 34:418-421(1996). Yokoyama M., Brain Res. Mol. Brain Res. 42:135-139(1996). Miyachi T., Brain Res. Mol. Brain Res. 69:223-231(1999) Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:NEUROD1 Research Areas:Epigenetics and Nuclear Signaling?Neuroscience?Cancer?CardiovascµLar;Metabolism