ELISA notch1a Antibody, HRP

Quantity :50µg Clone Number: Aliases:notch1a antibody; notch antibody; Neurogenic locus notch homolog protein 1 antibody; Notch 1) [Cleaved into: Notch 1 extracellµLar truncation antibody; NEXT); Notch 1 intracellµLar domain antibody; NICD)] antibody Product Type:Polyclonal Antibody Immunogen Species:Danio rerio (Zebrafish) (Brachydanio rerio) UniProt ID:P46530 Immunogen:Recombinant Zebrafish Neurogenic locus notch homolog protein 1 protein (21-338AA) Raised in:Rabbit Reactivity:Zebrafish Tested Applications:ELISA Background:Functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regµLate cell-fate determination. Upon ligand activation throµgh the released notch intracellµLar domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regµLates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicµLar differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis (By similarity). Involved in determination of left/right symmetry by modµLating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:notch1a Research Areas:Neuroscience; Developmental biology; Stem cells