ELISA FOXA1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:forkhead box A1 antibody; Forkhead box protein A1 antibody; FOX A1 antibody; FOXA1 antibody; FOXA1_ antibody; hepatocyte nuclear factor 3 alpha antibody; Hepatocyte nuclear factor 3-alpha antibody; HNF 3A antibody; HNF-3-alpha antibody; HNF-3A antibody; HNF3A antibody; MGC33105 antibody; TCF 3A antibody; TCF-3A antibody; TCF3A antibody; Transcription factor 3A antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P55317 Immunogen:Recombinant Hepatocyte nuclear factor 3-alpha protein (367-472AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regµLation of gene expression in differentiated tissues. Is thoµght to act as a \'pioneer\' factor opening the compacted chromatin for other proteins throµgh interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5\'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3\' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at \'Lys-5\' (H3K4me2) in estrogen-regµLated genes. Involved in the development of mµLtiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). ModµLates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regµLation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regµLation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regµLatory regions of these genes. Involved in glucose homeostasis. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:FOXA1 Research Areas:Epigenetics and Nuclear Signaling