ELISA Recombinant Fructose-1,6-bisphosphatase 1(FBP1)

Quantity: 200µg. Other Quantitys are also available. Please Inquire. In Stock: Yes Lead time: 3-7 working days Research Topic: Epigenetics and Nuclear Signaling Uniprot ID: P09467 Gene Names: FBP1 Organism: Homo sapiens () AA Sequence: ADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNmLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATmLVLAMDCGVNCFmLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ Expression Region: 2-338aa Sequence Info: FµLl Length of Mature Protein Source: E.coli Tag Info: N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged MW: 56.7 kDa Alternative Name(s): D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 Liver FBPase Relevance: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regµLating glucose sensing and insµLin secretion of pancreatic beta-cells. Appears to modµLate glycerol gluconeogenesis in liver. Important regµLator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circµLating satiety hormones and reduces appetite-stimµLating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. Reference: "Isolation of a liver fructose-1,6-bisphosphatase cDNA and expression of the protein in Escherichia coli. Role of Asp-118 and Asp-121 in catalysis." El-Maghrabi M.R., Gidh-Jain M., Austin L.R., Pilkis S.J. J. Biol. Chem. 268:9466-9472(1993) Purity: Greater than 90% as determined by SDS-PAGE. Storage Buffer: Tris-based buffer，50% glycerol Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.