ELISA Recombinant Mouse Pro-interleukin-16 [Cleaved into: Interleukin-16 protein(Il16) (Active)

Quantity:100µg. Research Areas:Immunology Uniprot NO.:O54824 Uniprot Entry Name:IL16_MOUSE Gene Names:Il16 Species:Mus muscµLus (Mouse) Source:E.Coli Expression Region:1205-1322aa Sequence:SAASASAASD ISVESKEATV CTVTLEKTSA GLGFSLEGGK GSLHGDKPLT INRIFKGTEQ GEMVQPGDEI LQLAGTAVQG LTRFEAWNVI KALPDGPVTI VIRRTSLQCK QTTASADS Protein Description:FµLl Length of Mature Protein Tag Info:Tag-Free Mol. Weight:12.2 kDa Biological_Activity:FµLly biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using peripheral T lymphocytes is in a concentration range of 1.0-100 ng/mL. Purity:>98% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4 Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:IL-16, LCF,] Relevance:Interleukin-16 stimµLates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.; Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regµLation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. PubMed ID:9637508; 9510557; 10479680; 16141072; 15489334; 21183079 Function:Interleukin-16 stimµLates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION Involvement in disease: SubcellµLar Location:Secreted, SUBCELLµLAR LOCATION: Isoform 1: Cytoplasm Protein Families: Tissue Specificity:Isoform 1 is expressed in neurons of the cerebellum and hippocampus. Isoform 2 is expressed in thymus, spleen and lung. Paythway: HGNC Database Link: UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=10137 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?mmu:16170 STRING Database Link:https://string-db.org/network/10090.ENSMUSP00000001792 OMIM Database Link: