ELISA Recombinant Rhesus Macaque Interleukin-6 protein(IL6) (Active)

Quantity:100µg. Research Areas:Immunology Uniprot NO.:P51494 Uniprot Entry Name:IL6_MACMU Gene Names:IL6 Species:Macaca mµLatta (Rhesus macaque) Source:E.Coli Expression Region:28-212aa Sequence:M+APVLPGEDS KNVAAPHSQP LTSSERIDKH IRYILDGISA LRKETCNRSN MCESSKEALA ENNLNLPKMA EKDGCFQSGF NEDTCLVKII TGLLEFEVYL EYLQNRFESS EEQARAVQMS TKVLIQFLQK KAKNLDAITT PEPTTNASLL TKLQAQNQWL QDMTTHLILR SFKEFLQSNL RALRQM Protein Description:FµLl Length of Mature Protein Tag Info:Tag-Free Mol. Weight:21.1 kDa Biological_Activity:FµLly biologically active when compared to standard. The ED50 as determined by a cell proliferation assay usingIL-6-dependent murine 7TD1 cells is less than 0.1 ng/mL, corresponding to a specific activity of ? 1.0 × 107 IU/mg. Purity:>97% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4 Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:IL-6, Relevance:Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insµLin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity). {ECO:0000250}. PubMed ID:7561102 Function:Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insµLin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity). Involvement in disease: SubcellµLar Location:Secreted Protein Families:IL-6 superfamily Tissue Specificity: Paythway: HGNC Database Link: UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mmu&CID=3376 KEGG Database Link: STRING Database Link:https://string-db.org/network/9544.ENSMMUP00000026278 OMIM Database Link: