ELISA Recombinant Tumor necrosis factor ligand superfamily member 13B(TNFSF13B),partial (Active)

Quantity:100µg. Research Areas:Cancer Uniprot NO.:Q9Y275 Uniprot Entry Name:TN13B_ Gene Names:TNFSF13B,BAFF,BLYS,TALL1,TNFSF20,ZTNF4,UNQ401/PRO738 Species:Homo sapiens () Source:E.Coli Expression Region:M+134-285aa Sequence:M+AVQGPEETV TQDCLQLIAD SETPTIQKGS YTFVPWLLSF KRGSALEEKE NKILVKETGY FFIYGQVLYT DKTYAMGHLI QRKKVHVFGD ELSLVTLFRC IQNMPETLPN NSCYSAGIAK LEEGDELQLA IPRENAQISL DGDVTFFGAL KLL Protein Description:Partial Tag Info:Tag-Free Mol. Weight:17.2 kDa Biological_Activity:FµLly biologically active when compared to standard. The ED50 as determined by a mouse splenocyte survival assay is 0.5-2 µg/mL. Purity:>95% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 ?m filtered concentrated solution in PBS, pH 7.0. Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:B lymphocyte stimµLator, B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecµLe, TNF- and APOL-related leukocyte expressed ligand 1 Relevance:Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimµLation of B- and T-cell function and the regµLation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. {ECO:0000269|PubMed:10973284}.; Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. {ECO:0000250}.; Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimµLated monocytes and for B-cell survival. It can directly or indirectly regµLate the differential expression of a large number of genes involved in the innate immune response and the regµLation of apoptosis. {ECO:0000269|PubMed:10973284}. PubMed ID:10331498; 10359578; 10398604; 12867412; 22749832; 12975309; 15057823; 15489334; 10973284; 11853672; 11827482; 11862220 Function:Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimµLation of B- and T-cell function and the regµLation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Involvement in disease: SubcellµLar Location:Cell membrane, Single-pass type II membrane protein, SUBCELLµLAR LOCATION: Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted Protein Families:Tumor necrosis factor family Tissue Specificity:Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. Paythway:NF-kappaBsignalingpathway HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:11929 UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=525157 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:10673 STRING Database Link:https://string-db.org/network/9606.ENSP00000365048 OMIM Database Link:https://www.omim.org/entry/603969603969603969