ELISA MUSK anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscµLar junction(NMJ), the synapse between the motor neuron and the skeletal muscle(PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regµLates the formation of NMJs throµgh the regµLation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors(AChR) in the postsynaptic membrane. May regµLate AChR phosphorylation and clustering throµgh activation of ABL1 and Src family kinases which in turn regµLate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regµLation of AChR clustering. May positively regµLate Rho family GTPases throµgh FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regµLator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation(By similarity). Immunogen:muscle, skeletal, receptor tyrosine kinase Synonyms:CMS9, FADS Observed MW:97 kDa Uniprot ID:O15146 Reactivity:, Mouse Tested Application:ELISA, WB Recommended dilution:WB: 1:500 - 1:2000 Gene ID:4593 Research Area:Signal Transduction