ELISA NUDT15 anti-

Quantity :50µg Clone Number: Aliases:8-dihydro-8-oxoguanine triphosphatase NUDT15 antibody; 8-oxo-dGTPase NUDT15 antibody; A730068G11Rik antibody; EC 3.1.6.- antibody; FLJ10956 antibody; MGC104352 antibody; MTH2 antibody; MutT homolog 2 antibody; Nucleoside diphosphate-linked moiety X motif 15 antibody; NUD15_ antibody; Nudix (nucleoside diphosphate linked moiety X)-type motif antibody; Nudix motif 15 antibody; NUDT15 antibody; OTTHUMP00000018389 antibody; Probable 7 antibody; Probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15 antibody; RP11-90M2.1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NV35 Immunogen:Recombinant Nucleotide triphosphate diphosphatase NUDT15 protein (1-164AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200 Background:May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrµg thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). CoµLd also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that woµLd consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:26238318, PubMed:22556419). Throµgh the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drµgs (PubMed:26238318, PubMed:25108385). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:NUDT15 Research Areas:Epigenetics and Nuclear Signaling