ELISA NMRAL1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:FLJ25918 antibody; HSCARG antibody; NmrA like family domain containing 1 antibody; NmrA like family domain containing protein 1 antibody; NmrA-like family domain-containing protein 1 antibody; NMRAL1 antibody; NMRL1_ antibody; SDR48A1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9HBL8 Immunogen:Recombinant NmrA-like family domain-containing protein 1 protein (1-299AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Redox sensor protein. Undergoes restructuring and subcellµLar redistribution in response to changes in intracellµLar NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecµLe of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:NMRAL1 Research Areas:Metabolism; Signal transduction