ELISA RFFL anti-

Quantity :50µL Clone Number: Aliases:CARP-2 antibody; CARP2 antibody; Caspase regµLator CARP2 antibody; Caspases 8 and 10 associated RING finger protein 2 antibody; caspases-8 and -10- associated RING finger protein 2 antibody; Caspases-8 and -10-associated RING finger protein 2 antibody; E3 ubiquitin protein ligase rififylin antibody; E3 ubiquitin-protein ligase rififylin antibody; Fring antibody; FYVE RING finger protein Sakura antibody; FYVE-RING finger protein Sakura antibody; Rffl antibody; RFFL_ antibody; Rififylin antibody; RING finger and FYVE like domain containing protein antibody; RING finger and FYVE-like domain-containing protein 1 antibody; RING finger protein 189 antibody; RING finger protein 34 like antibody; RING finger protein 34-like antibody; RNF189 antibody; RNF34L antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8WZ73 Immunogen:Recombinant E3 ubiquitin-protein ligase rififylin protein (1-190AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:E3 ubiquitin-protein ligase that regµLates several biological processes throµgh the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates \\\'Lys-48\\\'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regµLating cell migration throµgh the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regµLate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regµLates the tumor necrosis factor-mediated signaling pathway throµgh targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regµLates p53/TP53 throµgh its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regµLate p53/TP53 throµgh ubiquitination and degradation of SFN. May also play a role in endocytic recycling. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RFFL Research Areas:Epigenetics and Nuclear Signaling; Cell biology; Signal transduction