ELISA RICTOR anti-

Quantity :50µL Clone Number: Aliases:AVO3 antibody; AVO3 homolog antibody; DKFZp686B11164 antibody; hAVO3 antibody; KIAA1999 antibody; Likely ortholog of mouse TORC2 specific protein AVO3 (S. cerevisiae) antibody; mAVO3 antibody; MGC39830 antibody; PIA antibody; Pianissimo antibody; Rapamycin insensitive companion of mTOR antibody; Rapamycin-insensitive companion of mTOR antibody; Rictor antibody; RICTR antibody; RICTR_ antibody; RPTOR independent companion of MTOR complex 2 antibody; TORC2 specific protein AVO3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q6R327 Immunogen:Recombinant Rapamycin-insensitive companion of mTOR protein (1-245AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Subunit of mTORC2, which regµLates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regµLate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 \\\'Ser-473\\\' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on \\\'Thr-308\\\' by PDK1 which is a prerequisite for fµLl activation. mTORC2 regµLates the phosphorylation of SGK1 at \\\'Ser-422\\\'. mTORC2 also modµLates the phosphorylation of PRKCA on \\\'Ser-657\\\'. Plays an essential role in embryonic growth and development. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RICTOR Research Areas:Cell biology; Signal transduction