ELISA PLA2R1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:180 kDa secretory phospholipase A2 receptor antibody; C-type lectin domain family 13 member C antibody; CLEC13C antibody; M type receptor antibody; M-type receptor antibody; Phospholipase A2 receptor 1 antibody; PLA2 R antibody; PLA2-R antibody; PLA2G1R antibody; PLA2IR antibody; PLA2R antibody; PLA2R_ antibody; PLA2R1 antibody; Soluble PLA2-R antibody; Soluble PLA2R antibody; Soluble secretory phospholipase A2 receptor antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13018 Immunogen:Recombinant Secretory phospholipase A2 receptor protein (395-530AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Althoµgh its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regµLation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimµLate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particµLarly important for the clearance of extracellµLar sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circµLating and acts as a negative regµLator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PLA2R1 Research Areas:CardiovascµLar; Metabolism; Signal transduction