ELISA MED12 anti-

Quantity :100µL Clone Number: Aliases:Activator recruited cofactor 240 kDa component antibody; Activator-recruited cofactor 240 kDa component antibody; ARC240 antibody; CAG repeat protein 45 antibody; CAGH45 antibody; HOPA antibody; KIAA0192 antibody; MED12 antibody; MED12_ antibody; Mediator complex subunit 12 antibody; Mediator of RNA polymerase II transcription subunit 12 antibody; OPA containing protein antibody; OPA-containing protein antibody; Thyroid hormone receptor associated protein complex 230 kDa component antibody; Thyroid hormone receptor-associated protein complex 230 kDa component antibody; TNRC11 antibody; Trap230 antibody; Trinucleotide repeat containing gene 11 protein antibody; Trinucleotide repeat-containing gene 11 protein antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q93074 Immunogen:SyntheQuantityd peptide derived from internal of MED12. Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; IHC:1:50-1:100 Background:Component of the Mediator complex, a coactivator involved in the regµLated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regµLatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regµLatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regµLate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. Ito M., Mol. Cell 3:361-370(1999). Nagase T., DNA Res. 3:17-24(1996). Philibert R.A., Mol. Psychiatry 3:303-309(1998). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:MED12 Research Areas:Epigenetics and Nuclear Signaling