ELISA RARRES2 Antibody, FITC

Quantity :50µg Clone Number: Aliases:HP10433 antibody; RAR responsive protein TIG2 antibody; RAR-responsive protein TIG2 antibody; RARR2_ antibody; RARRES2 antibody; Retinoic acid receptor responder (tazarotene induced) 2 antibody; Retinoic acid receptor responder 2 antibody; Retinoic acid receptor responder protein 2 antibody; Tazarotene induced gene 2 protein antibody; Tazarotene-induced gene 2 protein antibody; TIG2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q99969 Immunogen:Recombinant Retinoic acid receptor responder protein 2 protein (21-157AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Adipocyte-secreted protein (adipokine) that regµLates adipogenesis, metabolism and inflammation throµgh activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regµLates adipocyte differentiation, modµLates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insµLin sensitivity, altered glucose and lipid metabolism, and a decrease in vascµLar function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte popµLations expressing CMKLR1, particµLarly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascµLar endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 throµgh stimµLation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascµLar disease. Exhibits an antimicrobial function in the skin. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RARRES2 Research Areas:Cancer; CardiovascµLar; Metabolism; Signal transduction