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ELISA PAK1|PAK2|PAK3 (Ab-423|402|421) anti-

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Quantity :100µL Clone Number: Aliases:ADRB2 antibody; Alpha PAK antibody; Alpha-PAK antibody; MGC130000 antibody; MGC130001 antibody; p21 activated kinase 1 antibody; p21 protein (Cdc42/Rac) activated kinase 1 antibody; p21-activated kinase 1 antibody; p21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related) antibody; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) antibody; p65 PAK antibody; p65-PAK antibody; P68-PAK antibody; PAK alpha antibody; PAK-1 antibody; Pak1 antibody; PAK1_ antibody; Paka antibody; PAKalpha antibody; Protein kinase MUK2 antibody; Rac/p21-activated kinase antibody; Serine/threonine-protein kinase PAK 1 antibody; STE20 homolog yeast antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13153 Immunogen:SyntheQuantityd non-phosphopeptide derived from PAK1/2/3 around the phosphorylation site of threonine 423/402/421 (R-S-T(p)-M-V). Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regµLation, cell migration, or cell cycle regµLation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 resµLts in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regµLator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modµLate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. Bernadett Boda, J. Neurosci., Dec 2004; 24: 10816 - 10825. Donna L. McPhie, J. Neurosci., JµL 2003; 23: 6914. Jin-Hun Jung, J. Biol. Chem., Dec 2005; 280: 40025 - 40031. Guo-Lei Zhou, Mol. Cell. Biol., Nov 2003; 23: 8058 - 8069. Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PAK1/PAK2/PAK3 Research Areas:Cancer;Cell biology;Signal transduction

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772,20 €

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