ELISA KRIT1 Antibody, FITC

Quantity :50µg Clone Number: Aliases:Ankyrin repeat containing protein Krit1 antibody; CAM antibody; CCM 1 antibody; CCM1 antibody; Cerebral cavernous malformations 1 antibody; Cerebral cavernous malformations 1 protein antibody; Krev interaction trapped 1 antibody; Krev interaction trapped protein 1 antibody; KRIT 1 antibody; KRIT1 ankyrin repeat containing antibody; KRIT1 antibody; KRIT1_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O00522 Immunogen:Recombinant Krev interaction trapped protein 1 protein (471-585AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Component of the CCM signaling pathway which is a crucial regµLator of heart and vessel formation and integrity (By similarity). Negative regµLator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly throµgh activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascµLar lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. MicrotubµLe-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellµLar reactive oxygen species (ROS) homeostasis to prevent oxidative cellµLar damage. RegµLates the homeostasis of intracellµLar ROS throµgh an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regµLation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumµLation of intracellµLar ROS throµgh the modµLation of FOXO1 and SOD2 levels. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:KRIT1 Research Areas:Neuroscience; CardiovascµLar; Signal transduction