ELISA KEAP1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Cytosolic inhibitor of Nrf2 antibody; INrf 2 antibody; INrf2 antibody; Keap 1 antibody; KEAP1 antibody; KEAP1_ antibody; Kelch like ECH associated protein 1 antibody; Kelch like family member 19 antibody; Kelch like protein 19 antibody; Kelch-like ECH-associated protein 1 antibody; Kelch-like protein 19 antibody; KIAA0132 antibody; KLHL 19 antibody; KLHL19 antibody; MGC10630 antibody; MGC1114 antibody; MGC20887 antibody; MGC4407 antibody; MGC9454 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q14145 Immunogen:Recombinant Kelch-like ECH-associated protein 1 protein (1-624AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CµL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resµLting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:KEAP1 Research Areas:Epigenetics and Nuclear Signaling