ELISA Recombinant Interleukin-11 protein(IL11) (Active)

Quantity:100µg. Research Areas:Immunology Uniprot NO.:P20809 Uniprot Entry Name:IL11_ Gene Names:IL11 Species:Homo sapiens () Source:E.Coli Expression Region:22-199aa Sequence:M+PGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL Protein Description:FµLl Length of Mature Protein Tag Info:Tag-Free Mol. Weight:19.1 kDa Biological_Activity:FµLly biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine B9-11 cells is less than 1 ng/mL, corresponding to a specific activity of ? 1.0 × 106 IU/mg. Purity:>95% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4 Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:IL-11, AGIF, Oprelvekin Relevance:Cytokine that stimµLates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resµLting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellµLar protein kinases and the phosphorylation of STAT3. {ECO:0000250|UniProtKB:P47873, ECO:0000269|PubMed:12919066, ECO:0000269|PubMed:2145578}. PubMed ID:2145578; 1828438; 1386338; 14702039; 15057824; 15489334; 12919066; 25195742 Function:Cytokine that stimµLates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resµLting in increased platelet production Involvement in disease: SubcellµLar Location:Secreted Protein Families:IL-6 superfamily Tissue Specificity: Paythway:Jak-STATsignalingpathway HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:5966 UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=467304 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:3589 STRING Database Link:https://string-db.org/network/9606.ENSP00000264563 OMIM Database Link:https://www.omim.org/entry/147681147681147681